RPS5

Across TCGA pan-cancer cohorts, RPS5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RPS5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPS5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS5 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where RPS5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.061	<.001	12	view →
COAD	Female	All	+1.759	<.001	11	view →
KIRP	All	II,III,IV	+1.058	<.001	10	view →
LIHC	Female	II,III,IV	+1.560	<.001	9	view →
LUSC	Male	All	+0.564	<.001	4	view →
BRCA	Female	All	−0.280	.007	4	view →
CHOL	Male	All	+2.180	<.001	3	view →
READ	All	All	+0.800	.006	2	view →
BLCA	Male	All	+0.384	.046	2	view →
PRAD	All	All	+0.268	.046	2	view →
KICH	Female	All	−0.584	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RPS5–KIRC

Open the KIRC breakdown →