RPS4Y1

Across TCGA pan-cancer cohorts, RPS4Y1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RPS4Y1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where RPS4Y1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RPS4Y1 is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC, HNSC, and CCRCC are the cancer types where RPS4Y1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS4Y1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	−0.883	<.001	7	view →
HNSC	Male	III,IV	−0.450	<.001	7	view →
CCRCC	Male	All	−0.441	<.001	4	view →
COAD	Female	II,III,IV	−0.397	.006	2	view →
LUAD	Female	All	−0.363	.028	1	view →
LSCC	Female	All	−0.277	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RPS4Y1–PDAC

Open the PDAC breakdown →