Across TCGA patient cohorts, RPS4X mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS4X-associated genes across cancer lineages are PAI-1, Shc_pY317, and STAT3_pY705. Each is linked with RPS4X in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS4X-to-partner and partner-to-RPS4X results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS4X→partner) and Y-score (partner→RPS4X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.463	+3.000	.007	.036	3	1
UCEC	Shc_pY317 →	-0.177	-2.321	.020	.035	3	1
UCEC	STAT3_pY705 →	-0.426	-2.999	.001	.035	3	1
UCEC	ATM →	-0.593	-2.321	.009	.035	3	1
UCEC	Caspase-8 →	-0.279	-3.295	.027	.009	3	1
UCEC	ERK2 →	+0.197	+2.321	.041	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

RPS4X survival (RNA) · tumor vs normal (RNA) · all RPS4X data types