Across TCGA pan-cancer cohorts, RPS3AP12 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPS3AP12’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RPS3AP12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS3AP12 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
LIHC, PRAD, and STAD are the cancer types where RPS3AP12 tumor–normal differential expression is most reproducible.