RPS3A

Across TCGA patient cohorts, RPS3A mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS3A-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and FOXO3a_pS318_S321. Each is linked with RPS3A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS3A-to-partner and partner-to-RPS3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RPS3A-low versus RPS3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS3A→partner) and Y-score (partner→RPS3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.237	-2.999	.036	.035	3	1
UCEC	eIF4G →	+0.382	+3.169	.006	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-3.575	.012	.002	3	1
UCEC	Gab2 →	+0.390	+2.000	.015	.032	3	1
UCEC	GATA6 →	-0.148	-2.985	.033	.034	3	1
UCEC	INPP4B →	-0.374	-3.321	.010	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR_pY1068 by RPS3A expression — UCEC

Explore this box plot interactively →