RPS3

Across TCGA pan-cancer cohorts, RPS3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RPS3 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RPS3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RPS3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where RPS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.666	.025	8	view →
HNSC	OS	Median	All	1.000	0.959	.023	8	view →
PDAC	DFS	Tertile	IV	0.228	0.934	.024	6	view →
CCRCC	OS	Quartile	All	0.854	1.000	.014	5	view →
GBM	DFS	Quartile	All	0.237	0.466	.031	3	view →
LUAD	DFS	Quartile	All	1.000	0.845	.007	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RPS3–LSCC (OS)

Open the LSCC breakdown →