RPS3

Across TCGA patient cohorts, RPS3 mutation is significantly associated with the RNA expression of many other genes, with 336 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS3-associated genes across cancer lineages are RNU6-502P, VN1R96P, and TRBVB. Each is linked with RPS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS3-to-partner and partner-to-RPS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-502P grouped by RPS3-low versus RPS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS3→partner) and Y-score (partner→RPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-502P →	+0.220	+3.008	<.001	.007	3	2
UCEC	VN1R96P →	+0.103	+2.214	<.001	.009	3	2
SKCM	TRBVB →	+0.221	+5.970	.003	.002	3	1
UCEC	MIR8082 →	+0.406	+2.824	<.001	<.001	3	1
UCEC	TRBV18 →	+0.570	+2.818	.004	.001	3	1
UCEC	LINC00869 →	-0.638	-2.742	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 336 associations by consensus.

RNU6-502P by RPS3 expression — UCEC

Explore this box plot interactively →