Across TCGA pan-cancer cohorts, RPS27P29 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RPS27P29’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPS27P29 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS27P29 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
KIRC, LIHC, and PAAD are the cancer types where RPS27P29 tumor–normal differential expression is most reproducible.