Across TCGA pan-cancer cohorts, RPS27L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPS27L data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RPS27L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RPS27L expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where RPS27L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.599	0.328	.022	12	view →
HNSC	DFS	Median	IV	0.795	0.551	.006	6	view →
CCRCC	OS	Median	All	0.903	1.000	.013	4	view →
LSCC	DFS	Tertile	II,III,IV	0.535	0.875	.016	4	view →
LUAD	DFS	Quartile	II,III,IV	0.716	0.994	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RPS27L tumor-vs-normal RNA expression · all RPS27L data types