Q-omics provides the consensus-scored RPS27AP1 profile across patient tissues and cancer cell-line models. RPS27AP1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, RPS27AP1 is differentially expressed in 9, with the highest sampling consensus in COAD. Additionally, RPS27AP1 RNA expression shows 11,044 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and COAD as cancer lineages where RPS27AP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RPS27AP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RPS27AP1 survival associations across molecular data types. RPS27AP1 RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RPS27AP1 RNA expression–survival associations across cancer types. High RPS27AP1 expression shows unfavorable associations in ACC, KICH, UCEC and BRCA, but favorable associations in THCA and LUSC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for RPS27AP1 RNA expression.
This table summarizes RPS27AP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for RPS27AP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RPS27AP1 shows lower tumor expression in BRCA, UCEC and KICH and higher tumor expression in COAD, LUSC and KIRC. The COAD box plot shows higher RPS27AP1 RNA expression in tumor versus normal tissue (log2 FC = +0.425, t-test p = .001).
This table shows molecular features associated with RPS27AP1 in patient tissues and cancer cell lines. In patient samples, RPS27AP1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
