RPS27

Across TCGA pan-cancer cohorts, RPS27 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RPS27’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RPS27 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RPS27 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, COAD, and PDAC are the cancer types where RPS27 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS27 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+0.670	<.001	9	view →
COAD	Female	All	+0.511	<.001	9	view →
PDAC	Male	All	−1.108	<.001	8	view →
LSCC	Male	All	+0.826	<.001	8	view →
CCRCC	All	II,III,IV	+0.144	.001	6	view →
HNSC	All	All	+0.180	.006	5	view →
OV	All	All	+0.329	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

RPS27–LUAD

Open the LUAD breakdown →