Across TCGA pan-cancer cohorts, RPS26P58 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RPS26P58’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RPS26P58 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS26P58 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.
LIHC, COAD, and HNSC are the cancer types where RPS26P58 tumor–normal differential expression is most reproducible.