RPS2

Across TCGA patient cohorts, RPS2 mutation is significantly associated with the RNA expression of many other genes, with 848 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS2-associated genes across cancer lineages are MELK, MYEOV, and CAPZB. Each is linked with RPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS2-to-partner and partner-to-RPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MELK grouped by RPS2-low versus RPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS2→partner) and Y-score (partner→RPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MELK →	+0.945	+2.711	.001	.003	3	2
UCEC	MYEOV →	+1.228	+2.700	.002	.006	3	2
UCEC	CAPZB →	+0.467	+3.512	<.001	.002	3	2
BLCA	RN7SL74P →	+0.148	+3.948	<.001	.002	3	2
CESC	RPS13P4 →	+0.148	+4.193	<.001	.009	3	2
CESC	RPSAP38 →	+0.058	+5.196	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 848 associations by consensus.

MELK by RPS2 expression — UCEC

Explore this box plot interactively →