RPS18

Across TCGA patient cohorts, RPS18 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS18-associated genes across cancer lineages are IGFBP2, Ku80, and Notch1. Each is linked with RPS18 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS18-to-partner and partner-to-RPS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by RPS18-low versus RPS18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS18→partner) and Y-score (partner→RPS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.763	-3.000	.042	.037	3	1
UCEC	Ku80 →	+0.354	+2.817	.009	.036	3	1
UCEC	Notch1 →	+0.183	+2.817	.024	.036	3	1
UCEC	Annexin-1 →	+0.705	+3.000	.020	.037	3	1
UCEC	VEGFR2 →	+0.410	+3.013	.017	.019	3	1
UCEC	CD49b →	-0.340	-2.986	.038	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IGFBP2 by RPS18 expression — UCEC

Explore this box plot interactively →