Across TCGA pan-cancer cohorts, RPS17P14 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPS17P14’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RPS17P14 RNA is repressed in tumor relative to normal tissue. In most cancer types RPS17P14 is over-expressed in tumor, although a few such as THCA and ESCA show the opposite, repressed pattern.
THCA and ESCA are the cancer types where RPS17P14 tumor–normal differential expression is most reproducible.