Across TCGA pan-cancer cohorts, RPS15AP25 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RPS15AP25’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RPS15AP25 RNA is repressed in tumor relative to normal tissue. In most cancer types RPS15AP25 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.
LUSC, KICH, and KIRC are the cancer types where RPS15AP25 tumor–normal differential expression is most reproducible.