Across TCGA pan-cancer cohorts, RPS15AP18 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RPS15AP18’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RPS15AP18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS15AP18 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
COAD, LUAD, and KIRC are the cancer types where RPS15AP18 tumor–normal differential expression is most reproducible.