RPRML

Across TCGA pan-cancer cohorts, RPRML Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated RPRML data layer compared with 20 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPRML Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RPRML expression acts as an unfavorable survival marker.

HNSC are the cancer types where RPRML Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.001	0.743	<.001	39	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

RPRML–HNSC (OS)

Open the HNSC breakdown →