RPRML

Across TCGA patient cohorts, RPRML mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RPRML-associated genes across cancer lineages are RNU6-1183P, MIR4316, and SNORD115-3. Each is linked with RPRML in more than 1 cancer types. Because this analysis shows association rather than direction, both RPRML-to-partner and partner-to-RPRML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1183P grouped by RPRML-low versus RPRML-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRML→partner) and Y-score (partner→RPRML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1183P →	+0.627	+5.497	.001	.004	3	1
BLCA	MIR4316 →	+0.416	+5.106	<.001	.008	3	1
HNSC	SNORD115-3 →	+0.322	+7.954	<.001	.008	3	1
HNSC	MIR362 →	+0.552	+7.954	<.001	.008	3	1
BLCA	FOXR2 →	+0.771	+4.973	<.001	.009	3	1
HNSC	RN7SL379P →	+0.199	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

RNU6-1183P by RPRML expression — BLCA

Explore this box plot interactively →