RPRML

Across TCGA cell cohorts, RPRML RNA expression is significantly associated with the go_rna of many other GO terms, with 1,191 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RPRML-associated GO terms across cancer lineages are DNA-templated transcription initiation, tRNA transcription, and Establishment of RNA localization. Each is linked with RPRML in more than 10 cancer types. Because this analysis shows association rather than direction, both RPRML-to-partner and partner-to-RPRML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by RPRML-low versus RPRML-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRML→partner) and Y-score (partner→RPRML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DNA-templated transcription initiation →	+0.046	+0.134	.001	.005	2	11
PANCREAS	tRNA transcription →	+0.082	+0.167	<.001	.004	3	10
BREAST	Establishment of RNA localization →	+0.072	+0.141	<.001	.004	2	9
SOFT_TISSUE	RNA export from nucleus →	+0.064	+0.379	.001	.002	3	8
BREAST	U2-type prespliceosome assembly →	+0.102	+0.179	<.001	.007	2	9
BLOOD_Lymphoma	Regulation of DNA repair →	+0.028	+0.545	.004	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,191 associations by consensus.

DNA-templated transcription initiation by RPRML expression — BREAST

Explore this box plot interactively →