RPRML

Across TCGA cell cohorts, RPRML mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RPRML-associated genes across cancer lineages are PTH, OR52K2, and OR14A16. Each is linked with RPRML in more than 1 cancer types. Because this analysis shows association rather than direction, both RPRML-to-partner and partner-to-RPRML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by RPRML-low versus RPRML-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRML→partner) and Y-score (partner→RPRML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PTH →	+0.023	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	OR52K2 →	+0.012	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR14A16 →	+0.016	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP4-11 →	+0.038	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PTH by RPRML expression — BLOOD_Lymphoma

Explore this box plot interactively →