RPRD2

Across TCGA pan-cancer cohorts, RPRD2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RPRD2 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher RPRD2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPRD2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCS, KIRC, and STAD are the cancer types where RPRD2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.068	0.524	<.001	48	view →
KIRC	OS	Median	II,III,IV	0.054	0.806	<.001	36	view →
STAD	DFS	Median	All	0.205	0.714	<.001	9	view →
UCEC	DFS	Median	All	0.954	0.828	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RPRD2–UCS (DFS)

Open the UCS breakdown →