RPRD2

Across TCGA cell cohorts, RPRD2 mutation is significantly associated with the RNA expression of many other genes, with 203 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPRD2-associated genes across cancer lineages are PRKCQ, ZNF723, and OTOR. Each is linked with RPRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPRD2-to-partner and partner-to-RPRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKCQ grouped by RPRD2-low versus RPRD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPRD2→partner) and Y-score (partner→RPRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRKCQ →	+0.706	+2.523	.001	.003	3	2
OESOPHAGUS	ZNF723 →	+0.017	+4.392	<.001	.003	3	1
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	OR9K2 →	+0.020	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR1I1 →	+0.012	+4.681	<.001	.003	3	1
LARGE_INTESTINE	EIF3L →	+0.573	+2.526	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 203 associations by consensus.

PRKCQ by RPRD2 expression — LARGE_INTESTINE

Explore this box plot interactively →