RPRD1A

Across TCGA pan-cancer cohorts, RPRD1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPRD1A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPRD1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPRD1A expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, OV, and GBM are the cancer types where RPRD1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.490	0.810	.006	11	view →
OV	DFS	Tertile	All	0.814	1.000	.037	8	view →
GBM	OS	Tertile	All	0.657	0.382	.009	6	view →
LSCC	OS	Quartile	All	0.891	0.656	.038	1	view →
PDAC	OS	Median	All	0.310	0.499	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPRD1A–HNSC (DFS)

Open the HNSC breakdown →