RPP30

Across TCGA pan-cancer cohorts, RPP30 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RPP30 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RPP30 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RPP30 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where RPP30 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.879	0.425	.003	16	view →
CCRCC	OS	Tertile	III,IV	0.132	0.985	.038	12	view →
LUAD	OS	Median	III,IV	0.796	0.298	.019	4	view →
HNSC	DFS	Quartile	II,III,IV	0.596	0.827	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RPP30–LSCC (DFS)

Open the LSCC breakdown →