RPP30

Across TCGA patient cohorts, RPP30 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPP30-associated genes across cancer lineages are MEK1, p27_pT157, and p62 Lck ligand. Each is linked with RPP30 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPP30-to-partner and partner-to-RPP30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RPP30-low versus RPP30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP30→partner) and Y-score (partner→RPP30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.459	+3.700	.007	.001	3	1
UCEC	p27_pT157 →	-0.084	-3.156	.001	.018	3	1
UCEC	p62 Lck ligand →	+0.502	+2.584	<.001	.011	3	1
UCEC	Rab11 →	-0.181	-3.302	.007	.010	3	1
UCEC	S6_pS240_S244 →	+0.421	+2.584	.026	.011	3	1
UCEC	ASNS →	+0.480	+2.999	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

MEK1 by RPP30 expression — UCEC

Explore this box plot interactively →