RPP30

Across TCGA cell cohorts, RPP30 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,372 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RPP30-associated GO terms across cancer lineages are Spindle elongation, Regulation of mitotic sister chromatid separation, and Regulation of chromosome separation. Each is linked with RPP30 in more than 18 cancer types. Because this analysis shows association rather than direction, both RPP30-to-partner and partner-to-RPP30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by RPP30-low versus RPP30-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP30→partner) and Y-score (partner→RPP30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Spindle elongation →	+0.274	+1.232	.002	.005	3	19
KIDNEY	Regulation of mitotic sister chromatid separation →	+0.174	+1.017	<.001	<.001	3	18
KIDNEY	Regulation of chromosome separation →	+0.181	+1.158	<.001	<.001	3	18
KIDNEY	Negative regulation of mitotic sister chromatid separation →	+0.158	+0.761	<.001	.004	3	18
KIDNEY	Negative regulation of sister chromatid segregation →	+0.158	+0.761	<.001	.004	3	18
KIDNEY	Regulation of mitotic sister chromatid segregation →	+0.161	+1.025	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,372 associations by consensus.

Spindle elongation by RPP30 expression — LUNG_NSCLC_LUSC

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