RPP25L

Across TCGA pan-cancer cohorts, RPP25L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RPP25L data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RPP25L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RPP25L expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where RPP25L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.962	0.659	.007	32	view →
CCRCC	DFS	Median	II,III,IV	0.979	0.163	.003	13	view →
LSCC	DFS	Median	II,III,IV	0.874	0.655	.012	8	view →
PDAC	DFS	Tertile	IV	0.199	0.752	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RPP25L–LUAD (DFS)

Open the LUAD breakdown →