RPP25L

Across TCGA patient cohorts, RPP25L mutation is significantly associated with the RNA expression of many other genes, with 538 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPP25L-associated genes across cancer lineages are BNIP3P41, RNU6-207P, and RNA5SP165. Each is linked with RPP25L in more than 1 cancer types. Because this analysis shows association rather than direction, both RPP25L-to-partner and partner-to-RPP25L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P41 grouped by RPP25L-low versus RPP25L-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP25L→partner) and Y-score (partner→RPP25L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BNIP3P41 →	+0.024	+7.954	<.001	.008	3	2
SKCM	RNU6-207P →	+0.378	+6.199	<.001	.001	3	2
BLCA	RNA5SP165 →	+0.525	+4.331	<.001	.007	3	1
BLCA	CASC23 →	+0.042	+6.082	<.001	<.001	3	1
UCEC	PRODH →	+0.687	+3.617	.002	.001	3	1
UCEC	PPP6R2 →	+0.350	+2.815	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 538 associations by consensus.

BNIP3P41 by RPP25L expression — HNSC

Explore this box plot interactively →