RPP21

Across TCGA pan-cancer cohorts, RPP21 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RPP21 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RPP21 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RPP21 expression acts as an unfavorable survival marker, although some lineages such as BLCA and READ show a favorable association.

BLCA, KIRC, and ACC are the cancer types where RPP21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.618	0.413	<.001	70	view →
KIRC	DFS	Quartile	II,III,IV	0.578	0.776	<.001	62	view →
ACC	OS	Tertile	All	0.388	0.844	<.001	55	view →
KICH	OS	Quartile	All	0.424	1.000	<.001	35	view →
KIRP	DFS	Median	All	0.863	0.950	.003	35	view →
BRCA	DFS	Tertile	IV	0.393	0.909	.004	32	view →
ESCA	DFS	Tertile	III,IV	0.273	0.558	.004	30	view →
PRAD	DFS	Tertile	All	0.712	0.927	<.001	30	view →
LIHC	OS	Tertile	All	0.711	0.848	.004	30	view →
UCS	DFS	Tertile	IV	0.337	0.942	.024	24	view →
READ	OS	Median	All	0.746	0.575	.015	20	view →
SCLC	DFS	Median	All	0.753	0.492	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RPP21–BLCA (DFS)

Open the BLCA breakdown →