RPP14

Across TCGA pan-cancer cohorts, RPP14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPP14 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RPP14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPP14 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where RPP14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	IV	0.314	1.000	.006	32	view →
LSCC	DFS	Median	II,III,IV	0.882	0.521	<.001	29	view →
GBM	OS	Tertile	All	0.561	0.888	.004	17	view →
COAD	DFS	Median	IV	0.432	0.916	.038	6	view →
PDAC	DFS	Quartile	All	0.737	0.914	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPP14–CCRCC (DFS)

Open the CCRCC breakdown →