RPP14

Across TCGA patient cohorts, RPP14 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPP14-associated genes across cancer lineages are eEF2, Rictor_pT1135, and Caspase-7-cleavedD198. Each is linked with RPP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPP14-to-partner and partner-to-RPP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RPP14-low versus RPP14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPP14→partner) and Y-score (partner→RPP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.551	+3.000	.003	.036	3	1
UCEC	Rictor_pT1135 →	-0.147	-3.321	.006	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.819	+3.019	.008	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.228	-3.000	.009	.036	2	1
UCEC	MEK1 →	+0.659	+3.321	<.001	.010	2	1
UCEC	PDCD4 →	-0.682	-2.990	.005	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eEF2 by RPP14 expression — UCEC

Explore this box plot interactively →