RPN2

Across TCGA patient cohorts, RPN2 mutation is significantly associated with the RNA expression of many other genes, with 1,936 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPN2-associated genes across cancer lineages are FCGBP, TUBGCP5, and RNA5SP412. Each is linked with RPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPN2-to-partner and partner-to-RPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCGBP grouped by RPN2-low versus RPN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPN2→partner) and Y-score (partner→RPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCGBP →	-1.012	-1.689	<.001	.002	3	2
UCEC	TUBGCP5 →	+0.383	+2.118	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.550	+2.092	<.001	<.001	3	2
UCEC	CCDC74B →	-0.656	-2.305	.001	.001	3	2
UCEC	TYW3 →	+0.483	+2.628	<.001	<.001	3	2
UCEC	ABHD18 →	+0.377	+1.484	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,936 associations by consensus.

FCGBP by RPN2 expression — UCEC

Explore this box plot interactively →