RPN2

Across TCGA patient cohorts, RPN2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPN2-associated genes across cancer lineages are ARID1A, EGFR_pY1068, and ERK2. Each is linked with RPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPN2-to-partner and partner-to-RPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARID1A grouped by RPN2-low versus RPN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPN2→partner) and Y-score (partner→RPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARID1A →	-0.171	-2.574	.009	.010	3	2
UCEC	EGFR_pY1068 →	-0.273	-2.000	.001	.009	3	1
UCEC	ERK2 →	+0.191	+2.807	.003	.002	3	1
UCEC	FoxM1 →	+0.211	+1.247	.016	.045	3	1
UCEC	GAPDH →	+0.461	+2.000	.011	.029	3	1
UCEC	GATA6 →	-0.132	-1.700	.017	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ARID1A by RPN2 expression — UCEC

Explore this box plot interactively →