RPN1

Across TCGA pan-cancer cohorts, RPN1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RPN1 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher RPN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RPN1 expression acts as an unfavorable survival marker.

THYM, BLCA, and COAD are the cancer types where RPN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	DFS	Median	III,IV	0.121	0.575	<.001	30	view →
COAD	DFS	Median	All	0.136	0.571	.004	10	view →
BRCA	OS	Median	All	0.602	0.963	.008	8	view →
MESO	DFS	Median	All	0.098	0.366	.039	6	view →
LIHC	DFS	Median	All	0.096	0.543	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RPN1–THYM (OS)

Open the THYM breakdown →