RPN1

Across TCGA patient cohorts, RPN1 mutation is significantly associated with the RNA expression of many other genes, with 1,022 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPN1-associated genes across cancer lineages are MIR3908, RNU1-57P, and ELOA3CP. Each is linked with RPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPN1-to-partner and partner-to-RPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3908 grouped by RPN1-low versus RPN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPN1→partner) and Y-score (partner→RPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3908 →	+0.317	+6.149	<.001	<.001	3	2
STAD	RNU1-57P →	+0.799	+5.026	<.001	.009	3	2
BRCA	ELOA3CP →	+0.024	+7.731	<.001	.009	3	1
UCEC	BTBD10 →	+0.466	+2.147	.003	.009	3	1
UCEC	PGAP2 →	+0.436	+2.716	.002	.003	3	1
UCEC	INTS4 →	+0.311	+3.724	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,022 associations by consensus.

MIR3908 by RPN1 expression — COAD

Explore this box plot interactively →