RPN1

Across TCGA patient cohorts, RPN1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPN1-associated genes across cancer lineages are A-Raf_pS299, JNK2, and MEK1. Each is linked with RPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPN1-to-partner and partner-to-RPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RPN1-low versus RPN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPN1→partner) and Y-score (partner→RPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.128	-2.321	.011	.034	3	1
UCEC	JNK2 →	+0.315	+2.906	<.001	.001	3	1
UCEC	MEK1 →	+0.359	+3.584	.020	.002	3	1
UCEC	Rab25 →	-0.357	-2.999	.011	.035	3	1
UCEC	TFRC →	+0.455	+1.700	.043	.044	3	1
UCEC	Tuberin_pT1462 →	+0.299	+1.884	.002	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

A-Raf_pS299 by RPN1 expression — UCEC

Explore this box plot interactively →