RPN1

Across TCGA cell cohorts, RPN1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible RPN1-associated genes across cancer lineages are TGM6, HMGB4, and REG1B. Each is linked with RPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPN1-to-partner and partner-to-RPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by RPN1-low versus RPN1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPN1→partner) and Y-score (partner→RPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TGM6 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	HMGB4 →	+0.306	+5.000	<.001	.005	3	1
LARGE_INTESTINE	REG1B →	+2.047	+3.196	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TGM6 by RPN1 expression — KIDNEY

Explore this box plot interactively →