RPLP0P2

Across TCGA patient cohorts, RPLP0P2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPLP0P2-associated genes across cancer lineages are MSH2, Caspase-8, and EGFR. Each is linked with RPLP0P2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPLP0P2-to-partner and partner-to-RPLP0P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by RPLP0P2-low versus RPLP0P2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPLP0P2→partner) and Y-score (partner→RPLP0P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.381	-3.433	<.001	.005	3	2
UCEC	Caspase-8 →	-0.223	-3.432	.042	.005	3	2
UCEC	EGFR →	-0.148	-3.000	.033	.036	3	1
UCEC	MYH11 →	+1.088	+2.807	.030	.003	3	1
UCEC	Notch1 →	+0.212	+3.183	<.001	.009	3	1
UCEC	Chk2 →	-0.268	-2.807	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MSH2 by RPLP0P2 expression — UCEC

Explore this box plot interactively →