RPLP0

Across TCGA patient cohorts, RPLP0 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPLP0-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, p70-S6K_pT389, and PKC-delta_pS664. Each is linked with RPLP0 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPLP0-to-partner and partner-to-RPLP0 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by RPLP0-low versus RPLP0-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPLP0→partner) and Y-score (partner→RPLP0) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.546	+2.321	.032	.035	3	1
UCEC	p70-S6K_pT389 →	-0.215	-2.999	.024	.035	3	1
UCEC	PKC-delta_pS664 →	-0.123	-2.321	.042	.035	2	1
UCEC	4E-BP1 →	+0.449	+2.321	<.001	.035	2	1
UCEC	p62 Lck ligand →	+0.328	+2.321	.045	.035	1	1
UCEC	TFRC →	+0.611	+2.321	.021	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Acetyl-a-Tubulin-Lys40 by RPLP0 expression — UCEC

Explore this box plot interactively →