RPL7L1

Across TCGA patient cohorts, RPL7L1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL7L1-associated genes across cancer lineages are IRS1, JNK_pT183_Y185, and MAPK_pT202_Y204. Each is linked with RPL7L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL7L1-to-partner and partner-to-RPL7L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by RPL7L1-low versus RPL7L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL7L1→partner) and Y-score (partner→RPL7L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+0.388	+3.000	.001	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.244	-3.000	.012	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.728	-3.000	.007	.036	3	1
UCEC	MEK1_p_S217_S221 →	-0.382	-3.000	.015	.036	3	1
UCEC	MEK1 →	+0.493	+3.000	.019	.036	3	1
UCEC	p62 Lck ligand →	+0.669	+2.817	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

IRS1 by RPL7L1 expression — UCEC

Explore this box plot interactively →