Across TCGA pan-cancer cohorts, RPL7AP69 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL7AP69’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RPL7AP69 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPL7AP69 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
KIRC and THCA are the cancer types where RPL7AP69 tumor–normal differential expression is most reproducible.