RPL7AP15

Across TCGA pan-cancer cohorts, RPL7AP15 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RPL7AP15’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RPL7AP15 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL7AP15 is over-expressed in tumor, although a few such as LUSC and ESCA show the opposite, repressed pattern.

LUSC, HNSC, and PRAD are the cancer types where RPL7AP15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL7AP15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.172	<.001	4	view →
HNSC	Male	III,IV	+0.063	.013	3	view →
PRAD	All	All	+0.090	.029	2	view →
ESCA	All	All	−0.866	.011	1	view →
THCA	All	IV	+0.152	.044	1	view →
LUAD	All	III,IV	−0.146	.024	1	view →
COAD	Male	III,IV	−0.113	.044	1	view →
KIRP	All	All	−0.085	.045	1	view →
LIHC	All	All	+0.076	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RPL7AP15–LUSC

Open the LUSC breakdown →