RPL7A

Across TCGA patient cohorts, RPL7A mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL7A-associated genes across cancer lineages are EGFR_pY1068, Ku80, and Annexin-1. Each is linked with RPL7A in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL7A-to-partner and partner-to-RPL7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RPL7A-low versus RPL7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL7A→partner) and Y-score (partner→RPL7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.351	-3.000	.007	.036	3	1
UCEC	Ku80 →	+0.364	+3.335	.003	.005	3	1
UCEC	Annexin-1 →	+0.858	+3.019	.001	.019	3	1
UCEC	BRD4 →	+0.368	+3.329	.008	.005	3	1
UCEC	Caspase-8 →	-0.320	-2.973	.015	.035	3	1
UCEC	Cyclin-B1 →	+0.934	+2.999	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by RPL7A expression — UCEC

Explore this box plot interactively →