Across TCGA pan-cancer cohorts, RPL6P21 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RPL6P21’s most consistent transcriptional readouts.

The strongest signal is observed in esophageal carcinoma (ESCA), where RPL6P21 RNA is repressed in tumor relative to normal tissue. In most cancer types RPL6P21 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.

ESCA and COAD are the cancer types where RPL6P21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPL6P21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
ESCA	Female	All	−0.056	.022	1	view →
COAD	All	All	+0.044	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: RPL6P21 RNA expression & survival · all RPL6P21 data types