RPL6

Across TCGA patient cohorts, RPL6 mutation is significantly associated with the RNA expression of many other genes, with 2,327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL6-associated genes across cancer lineages are RNU6-537P, LINC00507, and RNA5SP491. Each is linked with RPL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL6-to-partner and partner-to-RPL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-537P grouped by RPL6-low versus RPL6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL6→partner) and Y-score (partner→RPL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-537P →	+0.289	+5.444	<.001	.002	3	2
CESC	LINC00507 →	+0.016	+4.539	<.001	.008	3	2
UCEC	RNA5SP491 →	+0.294	+1.713	.003	.009	3	2
UCEC	RNA5SP418 →	+0.729	+2.162	<.001	.001	3	2
BLCA	MTATP6P4 →	+0.047	+4.588	<.001	.008	3	2
UCEC	ARRDC3-AS1 →	+0.242	+2.108	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,327 associations by consensus.

RNU6-537P by RPL6 expression — BLCA

Explore this box plot interactively →