RPL5

Across TCGA patient cohorts, RPL5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL5-associated genes across cancer lineages are Di-Ras3, eEF2, and MEK1. Each is linked with RPL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPL5-to-partner and partner-to-RPL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by RPL5-low versus RPL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL5→partner) and Y-score (partner→RPL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.130	-2.000	.013	.003	3	3
UCEC	eEF2 →	+0.271	+1.874	.031	.049	3	2
UCEC	MEK1 →	+0.363	+2.415	.004	.003	3	2
UCEC	Annexin-1 →	+0.556	+2.827	.002	.001	3	2
UCEC	Shc_pY317 →	-0.161	-2.321	.002	.005	3	2
UCEC	C-Raf →	+0.111	+1.362	.028	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Di-Ras3 by RPL5 expression — UCEC

Explore this box plot interactively →