RPL4

Across TCGA patient cohorts, RPL4 mutation is significantly associated with the RNA expression of many other genes, with 3,050 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL4-associated genes across cancer lineages are SUPV3L1, ATP6V0D1, and SMIM12. Each is linked with RPL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL4-to-partner and partner-to-RPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPV3L1 grouped by RPL4-low versus RPL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL4→partner) and Y-score (partner→RPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUPV3L1 →	+0.347	+3.501	.007	.002	3	2
UCEC	ATP6V0D1 →	+0.642	+4.087	<.001	<.001	3	2
UCEC	SMIM12 →	+0.338	+2.780	.005	.002	3	2
UCEC	GHITM →	+0.552	+2.662	.002	<.001	3	2
UCEC	TUBA1C →	+0.586	+2.169	.008	.003	3	2
UCEC	BANP →	+0.364	+3.601	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,050 associations by consensus.

SUPV3L1 by RPL4 expression — UCEC

Explore this box plot interactively →