RPL4

Across TCGA patient cohorts, RPL4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPL4-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and PDCD4. Each is linked with RPL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPL4-to-partner and partner-to-RPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by RPL4-low versus RPL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL4→partner) and Y-score (partner→RPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.203	-2.102	.005	.019	3	1
UCEC	MEK1 →	+0.506	+3.459	.001	.005	3	1
UCEC	PDCD4 →	-0.443	-2.449	.031	.019	3	1
UCEC	Tuberin →	+0.341	+2.807	.003	.003	3	1
UCEC	ASNS →	+0.379	+2.459	.016	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.842	+2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

JNK_pT183_Y185 by RPL4 expression — UCEC

Explore this box plot interactively →