RPL4

Across TCGA cell cohorts, RPL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,116 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RPL4-associated GO terms across cancer lineages are Positive regulation of canonical NF-kappaB signal transduction, Transcription initiation at mitochondrial promoter, and Regulation of leukocyte differentiation. Each is linked with RPL4 in more than 12 cancer types. Because this analysis shows association rather than direction, both RPL4-to-partner and partner-to-RPL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of canonical NF-kappaB signal transduction grouped by RPL4-low versus RPL4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPL4→partner) and Y-score (partner→RPL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of canonical NF-kappaB signal transduction →	-0.065	-0.669	<.001	.002	2	13
BLOOD_Lymphoma	Transcription initiation at mitochondrial promoter →	+0.099	+0.474	<.001	.001	3	11
LUNG_NSCLC_LUAD	Regulation of leukocyte differentiation →	-0.062	-0.612	<.001	<.001	3	11
STOMACH	Membrane raft organization →	-0.140	-0.745	.001	<.001	3	10
CNS	Plasma membrane organization →	-0.078	-0.717	.001	<.001	3	10
BONE	Actin filament organization →	-0.148	-0.657	<.001	.006	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,116 associations by consensus.

Positive regulation of canonical NF-kappaB signal transduction by RPL4 expression — BONE

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